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| Product Category: | Human lentivirus expressing PARP1 |
| Description: | Premade lentivirus for over-expression of human PARP1 and control, ready to use format. |
| Gene Name: | Poly(ADP-ribose) polymerase 1 |
| Gene Symbol: | PARP1 |
| Synonyms: | PARP; PARS; PPOL; ADPRT; ARTD1; ADPRT1; PARP-1; ADPRT 1; pADPRT-1; Poly-PARP |
| ACCN: | NM_001618.4 |
| Gene ID: | 142 |
| Vector: | VP002-CMV-MCS-3×Flag-EF1-ZsGreen |
| Fusion Tag: | Flag |
| Promoter: | CMV |
| Selection Antibiotic: | Puromycin |
| Titer: | ≥1E+8TU/ml |
| Buffer: | PBS |
| Storage: | -80°C |
| Documents: | Manual-Ready-to-Use Recombinant Lentivirus |
Background
The gene PARP1 encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
Optional Services
| Name | Catalog # | Turnaround Time | View |
| Gene Synthesis | S0012 | Quote |  |
| Lentivirus Packaging | S0032 | Quote | |
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