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| Product Category: | Human lentivirus expressing PIM1 |
| Description: | Premade lentivirus for over-expression of human PIM1 and control, ready to use format. |
| Gene Name: | Pim-1 proto-oncogene, serine/threonine kinase |
| Gene Symbol: | PIM1 |
| Synonyms: | PIM |
| ACCN: | NM_002648.4 |
| Gene ID: | 5292 |
| Vector: | VP094-CMV-MCS-3×Flag-EF1-ZsGreen-T2A-Hygromycin |
| Fusion Tag: | 3×Flag |
| Promoter: | CMV |
| Selection Antibiotic: | Hygromycin |
| Titer: | ≥1E+8TU/ml |
| Buffer: | PBS |
| Storage: | -80°C |
| Documents: | Manual-Ready-to-Use Recombinant Lentivirus |
Background
The protein encoded by the gene PIM1 belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).
Optional Services
| Name | Catalog # | Turnaround Time | View |
| Gene Synthesis | S0012 | Quote |  |
| Lentivirus Packaging | S0032 | Quote | |
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