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| Product Category: | Human lentivirus expressing PRKN |
| Description: | Premade lentivirus for over-expression of human PRKN and control, ready to use format. |
| Gene Name: | Parkin RBR E3 ubiquitin protein ligase |
| Gene Symbol: | PRKN |
| Synonyms: | PDJ; AR-JP; LPRS2; PARK2 |
| ACCN: | NM_004562.3 |
| Gene ID: | 5071 |
| Vector: | VP001-CMV-MCS-3×Flag-EF1-ZsGreen-T2A-PURO |
| Fusion Tag: | 3×Flag |
| Promoter: | CMV |
| Selection Antibiotic: | Puromycin |
| Titer: | ≥1E+8TU/ml |
| Buffer: | PBS |
| Storage: | -80°C |
| Documents: | Manual-Ready-to-Use Recombinant Lentivirus |
Background
The precise function of the gene PRKN is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.
Optional Services
| Name | Catalog # | Turnaround Time | View |
| Gene Synthesis | S0012 | Quote |  |
| Lentivirus Packaging | S0032 | Quote | |
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