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| Product Category: | Human lentivirus expressing PVT1 |
| Description: | Premade lentivirus for over-expression of human PVT1 and control, ready to use format. |
| Gene Name: | Pvt1 oncogene |
| Gene Symbol: | PVT1 |
| Synonyms: | TP53LC09; LINC00079; MIR1204HG; NCRNA00079; onco-lncRNA-100 |
| ACCN: | NC_000008.11 |
| Gene ID: | 5820 |
| Vector: | VP004-CMV-MCS-3×Flag-EF1-fLUC-T2A-PURO |
| Fusion Tag: | Flag |
| Promoter: | CMV |
| Selection Antibiotic: | Puromycin |
| Titer: | ≥1E+8TU/ml |
| Buffer: | PBS |
| Storage: | -80°C |
| Documents: | Manual-Ready-to-Use Recombinant Lentivirus |
Background
This gene represents a long non-coding RNA locus that has been identified as a candidate oncogene. Increased copy number and overexpression of this gene are associated with many types of cancers including breast and ovarian cancers, acute myeloid leukemia and Hodgkin lymphoma. Allelic variants of this gene are also associated with end-stage renal disease attributed to type 1 diabetes. Consistent with its association with various types of cancer, transcription of this gene is regulated by the tumor suppressor p53 through a canonical p53-binding site, and it has been implicated in regulating levels of the proto-oncogene MYC to promote tumorigenesis.
Optional Services
| Name | Catalog # | Turnaround Time | View |
| Gene Synthesis | S0012 | Quote |  |
| Lentivirus Packaging | S0032 | Quote | |
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