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| Product Category: | Human lentivirus expressing SOCS3 |
| Description: | Premade lentivirus for over-expression of human SOCS3 and control, ready to use format. |
| Gene Name: | suppressor of cytokine signaling 3 |
| Gene Symbol: | SOCS3 |
| Synonyms: | CIS3; SSI3; ATOD4; Cish3; SSI-3; SOCS-3 |
| ACCN: | NM_001378932.1, NM_001378933.1, NM_003955.5 |
| Gene ID: | 9021 |
| Vector: | pLKO-CMV-MCS-3×Flag -EF1-mcherry-t2a-puro |
| Fusion Tag: | Flag |
| Promoter: | CMV |
| Selection Antibiotic: | Puromycin |
| Titer: | ≥1E+8TU/ml |
| Buffer: | PBS |
| Storage: | -80°C |
| Documents: | Manual-Ready-to-Use Recombinant Lentivirus |
Background
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.
Optional Services
| Name | Catalog # | Turnaround Time | View |
| Gene Synthesis | S0012 | Quote |  |
| Lentivirus Packaging | S0032 | Quote | |
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