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| Product Category: | Human lentivirus expressing TP53 |
| Description: | Premade lentivirus for over-expression of human TP53 and control, ready to use format. |
| Gene Name: | Tumor protein p53 |
| Gene Symbol: | TP53 |
| Synonyms: | P53; BCC7; LFS1; BMFS5; TRP53 |
| ACCN: | NM_001126112.3 |
| Gene ID: | 7157 |
| Vector: | VP007-CMV-MCS-EF1-puro |
| Promoter: | CMV |
| Selection Antibiotic: | Puromycin |
| Titer: | ≥1E+8TU/ml |
| Buffer: | PBS |
| Storage: | -80°C |
| Documents: | Manual-Ready-to-Use Recombinant Lentivirus |
Background
The gene TP53 encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).
Optional Services
| Name | Catalog # | Turnaround Time | View |
| Gene Synthesis | S0012 | Quote |  |
| Lentivirus Packaging | S0032 | Quote | |
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