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Anti-24p3R Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Solute carrier family 22 member 17 |
Synonyms: | BOCT, BOIT, hBOIT, NgalR, NGALR3, NGALR2, Slc22a17, Lipocalin-2 receptor |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse 24p3R |
Uniprot ID: | Q9D9E0 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane |
Product Usage Information
IHC/IF | Human, Mouse, Rat | 1: 800-1: 2400 | liver, kidney, testis |
Background
Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis.
Images
| Immunohistochemistry analysis of paraffin embedded mouse liver using SLC22A17 (GB115001) at dilution of 1: 800 |
| Immunohistochemistry analysis of paraffin embedded rat liver using SLC22A17 (GB115001) at dilution of 1: 800 |
| Immunohistochemistry analysis of paraffin embedded human kidney using SLC22A17 (GB115001) at dilution of 1: 800 |
| Immunohistochemistry analysis of paraffin embedded rat kidney using SLC22A17 (GB115001) at dilution of 1: 800 |
| Immunohistochemistry analysis of paraffin embedded mouse kidney using SLC22A17 (GB115001) at dilution of 1: 800 |
| Immunohistochemistry analysis of paraffin embedded mouse testis using SLC22A17 (GB115001) at dilution of 1: 800 |
| Immunohistochemistry analysis of paraffin embedded rat testis using SLC22A17 (GB115001) at dilution of 1: 800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |