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| Reactivity: | Mouse |
| Applications: | WB, ELISA |
| Host Species: | Rabbit |
| Clonality: | Polyclonal antibody |
| Gene Name: | autophagy and beclin 1 regulator 1 |
| Gene Symbol: | AMBRA1 |
| Synonyms: | DCAF3; WDR94; Ambra1 |
| Gene ID: | 55626 |
| UniProt ID: | Q9C0C7 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 961-1208 of human Ambra1 (NP_060219.2). |
| Dilution: | WB 1:500-1:2000 |
| Purification Method: | Affinity purification |
| Concentration: | 0.33 mg/ml |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
| Documents: | Manual-AMBRA1 antibody |
Background
Enables GTPase binding activity and ubiquitin protein ligase binding activity. Involved in macroautophagy; positive regulation of phosphatidylinositol 3-kinase activity; and response to mitochondrial depolarisation. Located in cytosol. Colocalizes with mitochondrion. Biomarker of multiple system atrophy.
Images
 | Western blot analysis of lysates from mouse brain, using Ambra1 Rabbit pAb (A12578) at 1:1000 dilution._Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s. |
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