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Anti-AlkCDase 3 Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Alkaline ceramidase 3 |
Synonyms: | Aphc, Phca, Acer3, Alkaline CDase 3, Alkaline phytoceramidase |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse AlkCDase 3 |
Uniprot ID: | Q9D099 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Endoplasmic reticulum, Golgi apparatus, Membrane |
Product Usage Information
IHC/IF | Human | 1: 500-1: 1000 | placenta, lung cancer, liver cancer |
Background
Endoplasmic reticulum and Golgi ceramidase that catalyzes the hydrolysis of unsaturated long-chain C18:1-, C20:1- and C20:4-ceramides, dihydroceramides and phytoceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Controls the generation of sphingosine in erythrocytes, and thereby sphingosine-1-phosphate in plasma. Through the regulation of ceramides and sphingosine-1-phosphate homeostasis in the brain may play a role in neurons survival and function. By regulating the levels of proinflammatory ceramides in immune cells and tissues, may modulate the inflammatory response.
Images
| Immunohistochemistry analysis of paraffin embedded human placenta using APHC (GB114863) at dilution of 1: 500 |
| Immunohistochemistry analysis of paraffin embedded human lung cancer using APHC (GB114863) at dilution of 1: 500 |
| Immunohistochemistry analysis of paraffin embedded human liver cancer using APHC (GB114863) at dilution of 1: 500 |
| Immunofluorescence of paraffin embedded human liver cancer using APHC (GB114863) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |