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| Reactivity: | Human |
| Applications: | WB, IHC, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Polyclonal antibody |
| Gene Name: | claudin 4 |
| Gene Symbol: | CLDN4 |
| Synonyms: | CPER; CPE-R; CPETR; CPETR1; WBSCR8; hCPE-R; CLDN4 |
| Gene ID: | 1364 |
| UniProt ID: | O14493 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 109-209 of human CLDN4 (NP_001296.1). |
| Dilution: | WB 1:2000-1:4000; IHC 1:50-1:100 |
| Purification Method: | Affinity purification |
| Concentration: | 4.74 mg/ml |
| Buffer: | PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
| Documents: | Manual-CLDN4 antibody |
Background
The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.
Images
 | Western blot analysis of various lysates, using CLDN4 Rabbit pAb (A12912) at 1:4000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Negative control (NC): HL-60 Exposure time: 30s. |
 | Immunohistochemistry analysis of paraffin-embedded Human colon carcinoma using CLDN4 Rabbit pAb (A12912) at dilution of 1:150 (40x lens). Microwave antigen retrieval performed with 0.01M PBS Buffer (pH 7.2) prior to IHC staining. |
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