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Anti-DECTIN 2 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | C-type lectin domain family 6 member A |
Synonyms: | Clec4n, Clecsf10, Dectin2, Clec6a, DC-associated C-type lectin 2 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse CLEC6A |
Uniprot ID: | Q9JKF4 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 24 kDa / 35 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 300-1: 600 | heart, lung |
Background
Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas . Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes.Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production.Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses.
Images
| Western blot analysis of CLEC6A (GB114337) at dilution of 1: 500 |
| Western blot analysis of CLEC6A (GB114337) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |