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Glycophorin C (GYPC) Rabbit pAb (20 μl)
| Reactivity: | Human, Mouse |
| Applications: | WB, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Polyclonal antibody |
| Gene Name: | glycophorin C (Gerbich blood group) |
| Gene Symbol: | GYPC |
| Synonyms: | GE; GPC; GPD; GYPD; CD236; PAS-2; CD236R; PAS-2'; Glycophorin C (GYPC) |
| Gene ID: | 2995 |
| UniProt ID: | P04921 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-128 of human Glycophorin C (Glycophorin C (GYPC)) (NP_002092.1). |
| Dilution: | WB 1:500-1:2000 |
| Purification Method: | Affinity purification |
| Concentration: | 0.16 mg/ml |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
| Documents: | Manual-GYPC antibody |
Background
Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants.
Images
 | Western blot analysis of various lysates using Glycophorin C (GYPC) Rabbit pAb (A1232) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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