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Anti-Hey L Rabbit pAb (100 μl)
| Reactivity: | H,M,R & H,M |
| Applications: | IHC/IF & ICC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Hairy/enhancer-of-split related with YRPW motif-like protein |
Synonyms: | bHLHb33, HEY3, hHeyL, hHRT3, HRT-3, HRT3 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Hey L |
Uniprot ID: | Q9DBX7 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Product Usage Information
IHC/IF | Human, Mouse, Rat | 1: 800-1: 2400 | Kidney, oophoroma |
ICC/IF | Human, Mouse | 1: 100-1: 400 | HeLa |
Background
Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.
Images
| Immunohistochemistry analysis of paraffin embedded rat kidney using HeyL (GB1149728) at dilution of 1: 800 |
| Immunohistochemistry analysis of paraffin embedded human oophoroma using HeyL (GB1149728) at dilution of 1: 800 |
| Immunocytochemistry analysis of 4% paraformaldehyde-fixed HeLa cells using HeyL (GB114972) at dilution of 1: 200 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |