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| Reactivity: | Human, Mouse, Rat |
| Applications: | WB, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Polyclonal antibody |
| Gene Name: | klotho |
| Gene Symbol: | KL |
| Synonyms: | KLA; HFTC3; KL |
| Gene ID: | 9365 |
| UniProt ID: | Q9UEF7 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human KL (NP_004786.2). |
| Dilution: | WB 1:500-1:2000 |
| Purification Method: | Affinity purification |
| Buffer: | PBS with 0.09% Sodium azide, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
| Documents: | Manual-KL antibody |
Background
This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss.
Images
 | Western blot analysis of various lysates using KL Rabbit pAb (A12028) at 1:3000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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