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| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | MTM1 rabbit polyclonal |
Gene Name: | Myotubularin |
Synonyms: | CG2, CNM, MTM1, MTMX, myotubularin 1, XLMTM, Myotubular myopathy 1, KIAA4176 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse MTM1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 70 kDa |
Observed MW. | 70 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human | 1: 1000-1: 2000 | HeLa, A-431, U-251MG, Jurkat |
Background
The MTM1(Myotubularin) gene encodes a protein that belongs to a family of putative tyrosine phosphatases. It is required for muscle cell differentiation. The protein is also a potent phosphatidylinositol 3-phosphate (PI3P) phosphatase, which is a 66 kDa ubiquitous protein that is found mutated in the X-linked genetic disorder myotubular myopathy(XLMTM).MTM1 could therefore act as a regulator of the highly active phosphoinositide (PI) metabolism in cells, where interconversions of the eight PIs described so far is controlled by a set of specific kinases and phosphatases. MTM1 has two isoforms with the molecular mass of 66kDa and 70 kDa.
Images
 | Western blot analysis of MTM1 (GB113066) at dilution of 1: 2000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |