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| Reactivity: | Human, Rat |
| Applications: | WB, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Polyclonal antibody |
| Gene Name: | neuronal differentiation 1 |
| Gene Symbol: | NEUROD1 |
| Synonyms: | T2D; BETA2; BHF-1; MODY6; NEUROD; bHLHa3; NEUROD1 |
| Gene ID: | 4760 |
| UniProt ID: | Q13562 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 160-356 of human NEUROD1 (NP_002491.2). |
| Dilution: | WB 1:100-1:500 |
| Purification Method: | Affinity purification |
| Concentration: | 1.44 mg/ml |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
| Documents: | Manual-NEUROD1 antibody |
Background
This gene encodes a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus.
Images
 | Western blot analysis of various lysates using NEUROD1 Rabbit pAb (A1147) at 1:500 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 180s. |
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