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| Reactivity: | Human, Mouse, Rat |
| Applications: | WB, IHC, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Polyclonal antibody |
| Gene Name: | Oligodendrocyte transcription factor 2 |
| Gene Symbol: | OLIG2 |
| Synonyms: | BHLHB1; OLIGO2; RACK17; PRKCBP2; bHLHe19; Olig2 |
| Gene ID: | 10215 |
| UniProt ID: | Q13516 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-80 of human Olig2 (NP_005797.1). |
| Dilution: | WB 1:500-1:1000; IHC 1:50-1:100 |
| Purification Method: | Affinity purification |
| Concentration: | 1.47 mg/ml |
| Buffer: | PBS with 0.09% Sodium azide, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
| Documents: | Manual-OLIG2 antibody |
Background
This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome.
Images
 | Western blot analysis of various lysates using Olig2 Rabbit pAb (A12814) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
 | Immunohistochemistry analysis of paraffin-embedded Rat brain using Olig2 Rabbit pAb (A12814) at dilution of 1:200 (40x lens). Microwave antigen retrieval performed with 0.01M PBS Buffer (pH 7.2) prior to IHC staining. |
 | Immunohistochemistry analysis of paraffin-embedded Mouse brain using Olig2 Rabbit pAb (A12814) at dilution of 1:200 (40x lens). Microwave antigen retrieval performed with 0.01M PBS Buffer (pH 7.2) prior to IHC staining. |
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