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Anti-Optineurin Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Optineurin |
Synonyms: | FIP-2, FIP2, GLC1E, HIP7, HYPL, NRP, TFIIIA-INTP, OPTN, Huntingtin yeast partner L |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Optineurin |
Uniprot ID: | Q8K3K8 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm |
Product Usage Information
IHC/IF | Mouse, Rat | 1: 500-1: 1000 | testis, eyeball |
Background
OPTN, also named as FIP2, GLC1E, HIP7, HYPL and NRP, plays a neuroprotective role in the eye and optic nerve. It is probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. OPTN may act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). OPTN may constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death. Defects in OPTN are the cause of primary open angle glaucoma type 1E (GLC1E).
Images
| Immunohistochemistry analysis of paraffin embedded mouse testis using Optineurin (GB114324) at dilution of 1: 900 |
| Immunohistochemistry analysis of paraffin embedded rat testis using Optineurin (GB114324) at dilution of 1: 900 |
| Immunohistochemistry analysis of paraffin embedded rat eyeball using Optineurin (GB114324) at dilution of 1: 600 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |