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Anti-PTPN22 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: |
PTPN22 rabbit polyclonal |
| Gene Name: |
Tyrosine-protein phosphatase non-receptor type 22 |
|
Synonyms: |
Ptpn22, Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP, PEST-domain phosphatase, PEP, Ptpn8 |
| Immunogen: |
KLH conjugated Synthetic peptide corresponding to Mouse PTPN22 |
| Isotype: | IgG |
| Purity: | Affinity purification |
|
Predicted MW. |
90 kDa |
|
Observed MW. |
110 kDa |
| Uniprot ID: |
Product Usage Information
| Applications |
WB |
| Species |
Human, Mouse, Rat |
| Dilution |
1: 500-1: 1000 |
| Positive tissue |
spleen, thymus |
Background
This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Images
| Western blot analysis of PTPN22 (GB111046) at dilution of 1: 1000 Lane 1: U266 cell lysate Lane 2: U87 cell lysate Lane 3: THP-1 cell lysate Lane 4: Mouse spleen tissue lysate Lane 5: Mouse thymus tissue lysate |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |