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| Reactivity: | Human, Mouse, Rat |
| Applications: | WB, IP, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Polyclonal antibody |
| Gene Name: | RAB7A, member RAS oncogene family |
| Gene Symbol: | RAB7A |
| Synonyms: | RAB7; CMT2B; PRO2706 |
| Gene ID: | 7879 |
| UniProt ID: | P51149 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-207 of human RAB7 (NP_004628.4). |
| Dilution: | WB 1:500-1:1000 |
| Purification Method: | Affinity purification |
| Concentration: | 0.71 mg/ml |
| Buffer: | PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
| Documents: | Manual-RAB7A antibody |
Background
RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies.
Images
 | Western blot analysis of various lysates using RAB7 Rabbit pAb (A12784) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
 | Immunoprecipitation analysis of 300ug extracts of HeLa cells using 3ug RAB7 Rabbit pAb (A12784 1:200). Western blot was performed from the immunoprecipitate using RAB7 Rabbit pAb (A12784) at a dilition of 1:1000. |
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