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| Reactivity: | M,R |
| Applications: | IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | RRM2 rabbit polyclonal |
Gene Name: | Ribonucleoside-diphosphate reductase subunit M2 |
Synonyms: | Ribonucleotide reductase small chain, Ribonucleotide reductase small subunit, R2, RR2, RR2M, RRM2 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse RRM2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1: 1800-1: 3600 | lymph node, spleen |
Background
Ribonucleotide reductase M2 subunit is one of two subunits that constitute ribonucleotide reductase, the enzyme that catalyzes the conversion of ribonucleotide 5'-diphosphates into 2'-deoxyribonucleotides, a rate-limiting step in the production of 2'-deoxyribonucleoside 5'-diphosphates (dNTP) required for DNA synthesis and repair that is required for DNA synthesis and repair . RRM2 is only expressed during the late G1/early S phase, and degraded in late S phase, and the activity of RNR, and therefore DNA synthesis and cell proliferation, is controlled during the cell cycle by the synthesis and degradation of RRM2 subunit.
Images
| Immunohistochemistry analysis of paraffin-embedded mouse lymph node using RRM2 (GB112995) at dilution of 1: 3600 |
| Immunohistochemistry analysis of paraffin-embedded mouse spleen using RRM2 (GB112995) at dilution of 1: 3600 |
| Immunohistochemistry analysis of paraffin-embedded rat spleen using RRM2 (GB112995) at dilution of 1: 3600 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |