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Anti-Ryanodine Receptor Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | ryanodine receptor 1 (skeletal) |
Synonyms: | CCO, MHS, MHS1, Ryanodine receptor 1, RYDR, RYR, RYR 1, RYR1, SKRR |
Immunogen: | Recombinant protein corresponding to Mouse Ryanodine Receptor |
Uniprot ID: | E9PZQ0 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 565 kDa / 565 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 1000-1: 2000 | skeletal muscle |
Background
Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules . Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain . Required for normal embryonic development of muscle fibers and skeletal muscle . Required for normal heart morphogenesis, skin development and ossification during embryogenesis.
Images
| Western blot analysis of RYR1 (GB114160) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |