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| Reactivity: | Human, Mouse |
| Applications: | WB, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Polyclonal antibody |
| Gene Name: | snail family transcriptional repressor 2 |
| Gene Symbol: | SNAI2 |
| Synonyms: | SLUG; WS2D; SLUGH; SLUGH1; SNAIL2; Slug |
| Gene ID: | 6591 |
| UniProt ID: | O43623 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human Slug (NP_003059.1). |
| Dilution: | WB 1:500-1:1000 |
| Purification Method: | Affinity purification |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-SNAI2 antibody |
Background
This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects.
Images
 | Western blot analysis of lysates from Mouse spleen, using Slug Rabbit pAb (A1057) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 180s. |
 | Western blot analysis of lysates from HeLa cells, using Slug Rabbit pAb (A1057) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 180s. |
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