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| Reactivity: | Human, Mouse, Rat |
| Applications: | IHC, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Polyclonal antibody |
| Gene Name: | UDP-glucose 6-dehydrogenase |
| Gene Symbol: | UGDH |
| Synonyms: | GDH; UGD; DEE84; EIEE84; UDPGDH; UDP-GlcDH; UGDH |
| Gene ID: | 7358 |
| UniProt ID: | O60701 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 165-494 of human UGDH (NP_003350.1). |
| Dilution: | IHC 1:50-1:200 |
| Purification Method: | Affinity purification |
| Concentration: | 2.77 mg/ml |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
| Documents: | Manual-UGDH antibody |
Background
The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.
Images
 | Immunohistochemistry analysis of paraffin-embedded Rat liver using UGDH Rabbit pAb (A13559) at dilution of 1:100 (40x lens). Microwave antigen retrieval performed with 0.01M PBS Buffer (pH 7.2) prior to IHC staining. |
 | Immunohistochemistry analysis of paraffin-embedded Human esophagus using UGDH Rabbit pAb (A13559) at dilution of 1:100 (40x lens). Microwave antigen retrieval performed with 0.01M PBS Buffer (pH 7.2) prior to IHC staining. |
 | Immunohistochemistry analysis of paraffin-embedded Mouse kidney using UGDH Rabbit pAb (A13559) at dilution of 1:100 (40x lens). Microwave antigen retrieval performed with 0.01M PBS Buffer (pH 7.2) prior to IHC staining. |
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