ROR1 Rabbit mAb (100 μL)

Background

This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms.

Images

	Flow cytometry: 1×10^6 HEL cells (negative control,left) and MDA-MB-231 cells (right) were surface-stained with ROR1 Rabbit mAb (A24888,2 μg/mL,orange line) or ABflo® 647 Rabbit IgG isotype control (A22070,5 μl/Test,blue line), followed by Alexa Fluor® 647 conjugated goat anti-rabbit pAb staining. Non-fluorescently stained cells were used as blank control (red line).
	Flow cytometry: 1×10^6 MDA-MB-231 cells were surface-stained with ABflo® 647 Rabbit IgG isotype control (A22070,5 μl/Test,left) or ROR1 Rabbit mAb (A24888,2 μg/mL,right).

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