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| Reactivity: | Human |
| Applications: | IHC, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Polyclonal antibody |
| Gene Name: | S100 calcium binding protein A12 |
| Gene Symbol: | S100A12 |
| Synonyms: | p6; CAGC; CGRP; MRP6; CAAF1; MRP-6; ENRAGE; S100A12 |
| Gene ID: | 6283 |
| UniProt ID: | P80511 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-92 of human S100A12 (NP_005612.1). |
| Dilution: | IHC 1:100-1:500 |
| Purification Method: | Affinity purification |
| Concentration: | 2.91 mg/ml |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
| Documents: | Manual-S100A12 antibody |
Background
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. The protein includes an antimicrobial peptide which has antibacterial activity.
Images
 | Immunohistochemistry analysis of paraffin-embedded Human colon carcinoma using S100A12 Rabbit pAb (A12499) at dilution of 1:300 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate Bufferr (pH 6.0) prior to IHC staining. |
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