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| Reactivity: | Human, Mouse |
| Applications: | WB, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Polyclonal antibody |
| Gene Name: | sphingosine-1-phosphate receptor 1 |
| Gene Symbol: | S1PR1 |
| Synonyms: | EDG1; S1P1; CD363; ECGF1; EDG-1; CHEDG1; D1S3362; EDG1/HEXIM1 |
| Gene ID: | 1901 |
| UniProt ID: | P21453 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 303-382 of human EDG1/HEXIM1 (NP_001391.2). |
| Dilution: | WB 1:500-1:2000 |
| Purification Method: | Affinity purification |
| Concentration: | 0.31 mg/ml |
| Buffer: | PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
| Documents: | Manual-S1PR1 antibody |
Background
The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. Alternative splicing results in multiple transcript variants.
Images
 | Western blot analysis of various lysates using EDG1/HEXIM1 Rabbit pAb (A12935) at 1:3000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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