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| Reactivity: | Human, Mouse, Rat |
| Applications: | WB, IF/IC, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Polyclonal antibody |
| Gene Name: | SEL1L adaptor subunit of SYVN1 ubiquitin ligase |
| Gene Symbol: | SEL1L |
| Synonyms: | Hrd3; SEL1L1; PRO1063; SEL1-LIKE; SEL1L |
| Gene ID: | 6400 |
| UniProt ID: | Q9UBV2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-190 of human SEL1L (NP_005056.3). |
| Dilution: | WB 1:500-1:2000; IF/IC 1:50-1:200 |
| Purification Method: | Affinity purification |
| Concentration: | 2.12 mg/ml |
| Buffer: | PBS with 0.09% Sodium azide, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
| Documents: | Manual-SEL1L antibody |
Background
The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Images
 | Western blot analysis of various lysates, using SEL1L Rabbit pAb (A12073) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 180s. |
 | Immunofluorescence analysis of C6 cells using SEL1L Rabbit pAb (A12073) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of L929 cells using SEL1L Rabbit pAb (A12073) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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