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Anti-SLC4A4/NBC Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | SLC4A4/NBC rabbit polyclonal |
Gene Name: | Electrogenic sodium bicarbonate cotransporter 1 |
Synonyms: | Sodium bicarbonate cotransporter, Na(+)/HCO3(-) cotransporter, Solute carrier family 4 member 4, Slc4a4, Nbc1, Nbce1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse SLC4A4 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1: 1800-1: 3600 | kidney |
Background
SLC4A4 (Electrogenic sodium bicarbonate cotransporter 1) is an electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. It may regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. SLC4A4 interacts with carbonic anhydrase 2 and carbonic anhydrase 4 which may regulate transporter activity. There are four named isoforms produced by alternative splicing.This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis.
Images
| Immunohistochemistry analysis of paraffin-embedded mouse kidney using kNBC (GB112530) at dilution of 1: 3600 |
| Immunohistochemistry analysis of paraffin-embedded rat kidney using kNBC (GB112530) at dilution of 1: 3600 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |