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| Reactivity: | Human, Mouse, Rat |
| Applications: | WB, IHC, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Polyclonal antibody |
| Gene Name: | signal transducer and activator of transcription 1 |
| Gene Symbol: | STAT1 |
| Synonyms: | CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3; STAT91; STAT1 |
| Gene ID: | 6772 |
| UniProt ID: | P42224 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 513-712 of human STAT1 (NP_009330.1). |
| Dilution: | WB 1:2000-1:6000; IHC 1:50-1:200 |
| Purification Method: | Affinity purification |
| Concentration: | 0.72mg/ml |
| Buffer: | PBS with 0.09% Sodium azide, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-STAT1 antibody |
Background
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. The protein encoded by this gene can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. The protein plays an important role in immune responses to viral, fungal and mycobacterial pathogens. Mutations in this gene are associated with Immunodeficiency 31B, 31A, and 31C.
Images
 | Western blot analysis of various lysates using STAT1 Rabbit pAb (A0027) at 1:5000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 180s. |
 | Immunohistochemistry analysis of paraffin-embedded Human lung cancer using STAT1 Rabbit pAb (A0027) at dilution of 1:50 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate Bufferr (pH 6.0) prior to IHC staining. |
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