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| Reactivity: | M,R |
| Applications: | IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | AF10 rabbit polyclonal |
Gene Name: | Protein AF-10 |
Synonyms: | ALL1-fused gene from chromosome 10 protein, MLLT10, AF10, Type I AF10 protein |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human AF10 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1: 600-1: 1200 | testis |
Background
Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation.
Images
| Immunohistochemistry analysis of paraffin-embedded mouse testis using AF10 (GB112809) at dilution of 1: 1200 |
| Immunohistochemistry analysis of paraffin-embedded rat testis using AF10 (GB112809) at dilution of 1: 1200 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |