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Anti-AMPK beta 2 Rabbit pAb (100 μl)
| Reactivity: | H,M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | AMPK beta 2 rabbit polyclonal antibody |
Gene Name: | 5'-AMP-activated protein kinase subunit beta-2 |
Synonyms: | PRKAB2, protein kinase AMP activated noncatalytic subunit beta 2, AMPK beta 2, AAKB2, AMPK b2, AMPK β2 |
Immunogen: | Recombinant protein corresponding to Mouse AMPK beta 2 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 30 kDa |
Observed MW. | 34 kDa |
Uniprot ID: | O43741, Q6PAM0 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse | 1: 500-1: 1000 | lung, kidney |
Background
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles.
Images
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Western blot analysis of AMPKβ2 (GB11589) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |