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| Reactivity: | M,R & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | AQP0 rabbit polyclonal antibody |
Gene Name: | Lens fiber major intrinsic protein |
Synonyms: | Aquaporin-0, MIP26, MP26, MIP, AQP0 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human AQP0 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane |
Predicted MW. | 28 kDa |
Observed MW. | 28 kDa |
Uniprot ID: | P51180, P09011 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse, Rat | 1: 1000-1: 3000 | eye |
IHC/IF | Mouse, Rat | 1: 200-1: 600 | eye, liver, testis |
Background
Aquaporin 0 or MIP26 (major intrinsic protein 26kD), and Aquaporin 1 has been the foundation of the growing family of aquaporins. The lens specific Aquaporin 0 represents up to 80% of total lens membrane protein. Defects in Aquaporin 0 are a cause of autosomal recessive congenital cataract. The lens opacity mutation (LOP) is an AA substitution that inhibits targeting of MIP to the cell membrane. Human Aquaporin 0 is a 263 amino acid transmembrane protein belonging to the MIP family. Aquaporin families of proteins are predicted to contain six transmembrane domains.
Images
| Western blot analysis of AQP0 (GB112258) at dilution of 1: 1000 |
 | Immunohistochemistry of paraffin embedded rat eye using AQP0 (GB112258) at dilution of 1: 200 (400x lens) |
 | Immunofluorescence of paraffin embedded mouse testis using AQP0 (GB112258) at dilution of 1: 300 (300x lens) |
| Immunofluorescence of paraffin embedded rat liver using AQP0 (GB112258) at dilution of 1: 300 (400x lens) |
| Immunofluorescence of paraffin embedded rat testis using AQP0 (GB112258) at dilution of 1: 300 (300x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |