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Anti-ASAH2 Rabbit pAb (100 μl)
| Reactivity: | M |
| Applications: | IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | ASAH2 rabbit polyclonal |
Gene Name: | Neutral ceramidase |
Synonyms: | Acylsphingosine deacylase 2, ASAH2, hCD, HNAC1, LCDase, N CDase, NCDase, Non lysosomal ceramidase |
Immunogen: | Recombinant protein corresponding to Mouse ASAH2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane, Golgi apparatus, Mitochondrion, Secreted |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse | 1: 2100-1: 4200 | small intestine |
Background
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. Probably involved in the digestion of dietary sphingolipids in intestine by acting as a key enzyme for the catabolism of dietary sphingolipids and regulating the levels of bioactive sphingolipid metabolites in the intestinal tract.
Images
 | Immunohistochemistry analysis of paraffin-embedded mouse small intestine using ASAH2 (GB113476) at dilution of 1: 4200 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |