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Anti-ATG101 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | ATG101 rabbit polyclonal antibody |
Gene Name: | Autophagy-related protein 101 |
Synonyms: | Atg101, Atg13-interacting protein, C12orf44 , Chromosome 12 open reading frame 44 , FLJ11773 , OTTHUMP00000241687 |
Immunogen: | Recombinantproteincorrespondingto Mouse ATG101 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm |
Uniprot ID: | Q9D8Z6, Q6AY69 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 500-1: 1300 | brain, spleen |
Background
ATG101 is involved in autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. ATG101 is a recently discovered protein that stabilizes ATG13, another autophagy protein that forms a complex with the mammalian homologs of ATG1, ULK1 and ULK2, and with FIP200. This complex is a target of TOR phosphorylation under normal conditions inhibition of TOR by rapamycin or leucine deprivation leads to dephosphorylation of ATG13, ULK1 and ULK2, which then leads to autophagy.
Images
| Immunohistochemistry of paraffin embedded mouse brain using ATG101 (GB111681) at dilution of 1:650 (300x lens) |
| Immunohistochemistry of paraffin embedded rat brain using ATG101 (GB111681) at dilution of 1:650 (300x lens) |
| Immunofluorescence of paraffin embedded rat spleen using ATG101 (GB111681) at dilution of 1:650 (460x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |