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Anti-Aggrecan Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Aggrecan core protein |
Synonyms: | ACAN, AGC1, AGCAN, CSPG1, CSPGCP, MSK16, SEDK, Aggrecan |
Immunogen: | Recombinant protein corresponding to Mouse Aggrecan |
Uniprot ID: | Q61282 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Secreted, extracellular space, extracellular matrix |
Predicted MW. / Observed MW. | 222 kDa / 250 kDa |
Product Usage Information
IHC/IF | Human, Mouse, Rat | 1: 500-1: 1000 | Cartilage, bone |
Background
Aggrecan (ACAN), also known as cartilage-specific proteoglycan core protein (CSPCP) or chondroitin sulfate proteoglycan 1, is a protein that in humans is encoded by the ACAN gene. This gene is a member of the lectican (chondroitin sulfate proteoglycan) family. This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.
Images
| IHC analysis of Aggrecan(GB115687). |
| IHC analysis of Aggrecan(GB115687). |
| IHC analysis of Aggrecan(GB115687). Sample: Human bone, 4% PFA (G1101) 12-24h. Antigen retrieval: Citrate buffer (pH 6.0) (G1201), 98°C, 20 min. Primary antibody: 1: 1500, 4°C overnight. Secondary antibody: HRP conjugated Goat Anti-Rabbit lgG (H+L) (GB23303), 1: 200, RT, 1h. |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |