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Anti-Alpha-synuclein Rabbit pAb (100 μl)
| Reactivity: | M,R & H,M,R| M,R |
| Applications: | WB & IHC & ICC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Alpha-synuclein rabbit polyclonal |
Gene Name: | Alpha-synuclein |
Synonyms: | Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, NACP, Snca, Syn |
Immunogen: | Recombinant protein corresponding to Mouse Alpha-synuclein |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Predicted MW. | 14 kDa |
Observed MW. | 18 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse, Rat | 1: 500-1: 1000 | hippocampus |
IHC | Human, Mouse, Rat | 1: 1500-1: 3000 | cerebellum |
ICC | Human | 1: 800-1: 1600 | SH-SY5Y |
Background
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease.
Images
| Western blot analysis of Snca (GB112945) at dilution of 1: 1000 Lane 1: Mouse hippocampus tissue lysate Lane 2: Rat hippocampus tissue lysate |
| Immunohistochemistry analysis of paraffin-embedded human oligodendrocytoma using Snca (GB112945) at dilution of 1: 3000 |
| Immunohistochemistry analysis of paraffin-embedded mouse brain using Snca (GB112945) at dilution of 1: 3000 |
| Immunohistochemistry analysis of paraffin-embedded rat brain using Snca (GB112945) at dilution of 1: 3000 |
| Immunohistochemistry analysis of paraffin-embedded mouse cerebellum using Snca (GB112945) at dilution of 1: 3000 |
| Immunohistochemistry analysis of paraffin-embedded rat cerebellum using Snca (GB112945) at dilution of 1: 3000 |
| IImmunocytochemistry analysis of 4% paraformaldehyde-fixed SH-SY5Y cells using Alpha-synuclein GB112945 at dilution of 1: 1400 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |