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| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | MRP8 rabbit polyclonal antibody |
Gene Name: | Protein S100-A8 |
Synonyms: | S100A8, 60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MIF, MRP8, NIF, P8, S100 calcium |
Immunogen: | Recombinant protein corresponding to Mouse MRP8 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Secreted, Cytoskeleton, Cell membrane |
Uniprot ID: | P05109, P27005, P50115 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Mouse, Rat | 1:500-1:3000 | ovarian cancer, spleen, stomach |
Background
S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase.
Images
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Immunohistochemistry of paraffin embedded mouse spleen using S100A8 (GB11421) at dilution of 1:1500 (400x lens) |
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Immunohistochemistry of paraffin embedded rat spleen using S100A8 (GB11421) at dilution of 1:1500 (400x lens) |
 | Immunofluorescence of paraffin embedded human ovarian cancer using S100A8 (GB11421) at dilution of 1:1500 (400x lens) |
 | Immunofluorescence of paraffin embedded mouse spleen using S100A8 (GB11421) at dilution of 1:1500 (400x lens) |
 | Immunofluorescence of paraffin embedded rat stomach using S100A8 (GB11421) at dilution of 1:1500 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |