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| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | BAG family molecular chaperone regulator 1 |
Synonyms: | BAG 1, BAG1, BAG1L speicfic, BAG1M, BAG1S, HAP, RAP46 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Bag1 |
Uniprot ID: | Q60739 |
Isotype: | lgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Cytoplasm |
Product Usage Information
IHC/IF | Mouse, Rat | 1: 150-1: 600 | testis |
Background
Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain of HSPA8/HSC70. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.
Images
| Immunohistochemistry analysis of paraffin embedded mouse testis using Bag1 (GB115597) at dilution of 1: 150 |
| Immunohistochemistry analysis of paraffin embedded rat testis using Bag1 (GB115597) at dilution of 1: 150 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |