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Anti-Desmoplakin Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Desmoplakin rabbit polyclonal |
Gene Name: | Desmoplakin |
Synonyms: | Desmoplakin I, Desmoplakin II, DP, DPI, DPII, DSP, KPPS2, PPKS2, 250/210 kDa paraneoplastic pemphigus antigen |
Immunogen: | Recombinant protein corresponding to Mouse Desmoplakin |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Human, Mouse, Rat | 1: 500-1: 1000 | skin, esophagus, heart |
Background
The desmoplakin (DP) is the most abundant desmosomal proteins and is located at the cytoplasmic portion of the desmosomes which are specialized cell-cell adhesion structures abundant in tissues such as muscle and epidermis that are subjected to mechanical stress. Desmoplakin 1 and 2 (DP 1 and 2) are two splice variants sharing common C-terminal and N-terminal globular head and tail domains, but differ in the length of the rod domain that links them. This antibody detects both DP1 (280-330 kDa) and DP2 (240-260 kDa).
Images
| Immunohistochemistry analysis of paraffin-embedded mouse skin using DSP (GB113491) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded mouse esophagus using DSP (GB113491) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded rat esophagus using DSP (GB113491) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded mouse heart using DSP (GB113491) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded rat heart using DSP (GB113491) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |