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| Reactivity: | H & H |
| Applications: | WB & IHC/IF |
| Host Species: | Mouse |
| Clonality: | Monoclonal |
| Gene Name: | Erb-b2 receptor tyrosine kinase 2 |
Synonyms: | CD340, ERBB2, HER 2, HER 2/neu, HER2, MLN 19, MLN19, NEU, NGL, p185, p185erbB2, Proto oncogene c ErbB 2, Proto oncogene Neu, TKR1 |
Immunogen: | Recombinant protein corresponding to Human Erbb2 |
Uniprot ID: | P04626 |
Isotype: | IgG1,κ |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Cell membrane |
Predicted MW. / Observed MW. | 139 kDa / 185 kDa |
Product Usage Information
WB | Human | 1: 500-1: 1000 | SK-BR-3, SK-OV-3 |
IHC/IF | Human | 1: 250-1: 1000 | breast cancer |
Background
HER2, also known as ErbB2 and Neu, is a 185-kDa transmembrane glycoprotein that is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. It has no ligand binding domain of its own and therefore cannot bind growth factors.
Images
| Western blot analysis of ERBB2 (GB12327) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded human breast cancer using ERBB2 (GB12327) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded human breast cancer using ERBB2 (GB12327) at dilution of 1: 800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |