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Anti-FBXW8 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | F-box/WD repeat-containing protein 8 |
Synonyms: | FBW6, FBW8, FBX29, FBXO29) |
Immunogen: | Recombinant protein corresponding to Mouse FBXW8 |
Uniprot ID: | Q8BIA4 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 68 kDa / 70 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 500-1: 1000 | lung |
Background
Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation. Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (By similarity).
Images
| Western blot analysis of FBXW8 (GB114329) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |