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Anti-FOXL2 Rabbit pAb (100 μl)
| Reactivity: | M |
| Applications: | IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | FOXL2 rabbit polyclonal |
Gene Name: | Forkhead box protein L2 |
Synonyms: | Pituitary forkhead factor, P-Frk, Foxl2, Pfrk, BPES1, Blepharophimosis, PINTO, POF3 |
Immunogen: | Recombinant protein corresponding to Mouse FOXL2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse | 1: 3000-1: 6000 | ovary |
Background
Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis throught transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR.
Images
 | Immunohistochemistry analysis of paraffin-embedded mouse ovary using FOXL2 (GB113527) at dilution of 1: 6000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |