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Anti-HBEGF/DTR Rabbit pAb (100 μl)
| Reactivity: | H,R |
| Applications: | IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | HBEGF/DTR rabbit polyclonal |
Gene Name: | Proheparin-binding EGF-like growth factor |
Synonyms: | HB-EGF, HBEGF, Dtr, Hegfl, Diphtheria toxin receptor, Heparin-binding EGF-like growth factor |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse HBEGF/DTR |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Human, Rat | 1: 700-1: 1400 | cholangiocarcinoma, ovarian cancer, colon, esophagus, stomach |
Background
Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a 22kDa O-glycosylated protein that is a potent mitogen and chemoattractant for vascular smooth muscle cells, fibroblasts and epithelial cells but not endothelial cells. The natural protein has an apparent molecular mass of 19-23 kDa and exists in multiple forms as a result of heterogeneous O-glycosylation and/or Nterminal truncation. HB-EGF is synthesized as a membrane-anchored precursor(proHB-EGF) that is proteolytically cleaved to release the soluble mature growth factor.
Images
| Immunohistochemistry analysis of paraffin-embedded human cholangiocarcinoma using HBEGF (GB112926) at dilution of 1: 1700 |
| Immunohistochemistry analysis of paraffin-embedded human ovarian cancer using HBEGF (GB112926) at dilution of 1: 1700 |
| Immunohistochemistry analysis of paraffin-embedded human colon using HBEGF (GB112926) at dilution of 1: 1700 |
| Immunohistochemistry analysis of paraffin-embedded human esophagus using HBEGF (GB112926) at dilution of 1: 1700 |
| Immunohistochemistry analysis of paraffin-embedded rat stomach using HBEGF (GB112926) at dilution of 1: 1700 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |