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| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | HES1 rabbit polyclonal antibody |
Gene Name: | Transcription factor HES-1 |
Synonyms: | HES1, HES-1, HHL, HRY, bHLHb39, hes family bHLH transcription factor 1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse HES1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 30 kDa |
Observed MW. | 30 kDa |
Uniprot ID: | P35428 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse, Rat | 1: 500-1: 1000 | stomach, colon, lung |
Background
Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.
Images
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Western blot analysis of HES-1 (GB11374) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |