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| Reactivity: | H,M,R & H,M,R |
| Applications: | WB & IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | IDH2 rabbit polyclonal |
Gene Name: | Isocitrate dehydrogenase [NADP], mitochondrial |
Synonyms: | ICD M, IDH, IDH2, IDHM, IDP, IDPM, mNADP IDH, NADP(+) specific ICDH, Oxalosuccinate decarboxylase |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse IDH2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Mitochondrion |
Predicted MW. | 51 kDa |
Observed MW. | 45 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 1000-1: 2000 | brain, placenta, kidney, prostate |
IHC | Human, Mouse, Rat | 1: 500-1: 1000 | tonsili, kidney, heart |
Background
IDH2, also named as IDP and ICD-M, belongs to the isocitrate and isopropylmalate dehydrogenases family. It plays a role in intermediary metabolism and energy production. IDH2 is a mitochondrial NADP-dependent isocitrate dehydrogenase that catalyzes oxidative decarboxylation of isocitrate to alpha-ketoglutarate, producing NADPH. It may tightly associate or interact with the pyruvate dehydrogenase complex. IDH1 and IDH2 mutations could also contribute to tumorigenesis and cancer progression through increased mutagenesis.
Images
| Western blot analysis of IDH2 (GB113727) at dilution of 1: 2000 |
| Western blot analysis of IDH2 (GB113727) at dilution of 1: 2000 |
| Immunohistochemistry analysis of paraffin-embedded human tonsili using IDH2 (GB113727) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded human kidney using IDH2 (GB113727) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded mouse kidney using IDH2 (GB113727) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded rat kidney using IDH2 (GB113727) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded rat heart using IDH2 (GB113727) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |