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| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Insulin-like growth factor I |
Synonyms: | Igf-1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse IGF1 |
Uniprot ID: | P05017 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 20 kDa / 9, 13, 18, 20 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 300-1: 500 | lung, liver, PC-3 |
Background
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (By similarity).
Ca2+-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb.
Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways.
Images
| WB analysis of IGF1(GB115653). Sample: Protein treated by RIPA Lysis Buffer (G2002). |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |