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Anti-Integrin alpha V Rabbit pAb (100 μl)
| Reactivity: | H,R & H,R |
| Applications: | IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Integrin alpha V rabbit polyclonal |
Gene Name: | Integrin alpha-V |
Synonyms: | ITGAV, CD51, MSK8, VNRA, VTNR, integrin subunit alpha V |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Integrin alpha-V |
Isotype: | IgG |
Subcellular location: | |
Purity: | Affinity purification |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Human, Mouse, Rat | 1: 500-1: 2000 | liver cancer, kidney, brain |
IF | Human, Mouse, Rat | 1: 500-1: 1000 | liver cancer, kidney, brain |
Background
The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling . ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling . ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling. ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1.
Images
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Immunohistochemistry analysis of paraffin-embedded human liver cancer using Integrin alpha V (GB11293-2) at dilution of 1: 500 |
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Immunohistochemistry analysis of paraffin-embedded human kidney using Integrin alpha V (GB11293-2) at dilution of 1: 1000 |
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Immunohistochemistry analysis of paraffin-embedded mouse kidney using Integrin alpha V (GB11293-2) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |