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| Reactivity: | M & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | JP-2 rabbit polyclonal antibody |
Gene Name: | Junctophilin-2 |
Synonyms: | JP-2, Junctophilin type 2, JP2NT, Jph2, Jp2 |
Immunogen: | Recombinant protein corresponding to Mouse JP-2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Endoplasmic reticulum, Cell membrane, Nucleus |
Predicted MW. | 75 kDa |
Observed MW. | 80 kDa |
Uniprot ID: | Q9ET78 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse | 1: 1000-1: 2000 | skeletal muscle, heart |
IHC/IF | Mouse, Rat | 1: 300-1: 1200 | heart, Skeletal muscle |
Background
Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family. Alternative splicing has been observed at this locus and two variants encoding distinct isoforms are described.
Images
| Western blot analysis of JUNCTOPHILIN2 (GB112374) at dilution of 1: 1000 |
| Immunohistochemistry of paraffin embedded mouse heart using Junctophilin2 (GB112374) at dilution of 1: 600 (400x lens) |
| Immunohistochemistry of paraffin embedded mouse skeletal muscle using Junctophilin2 (GB112374) at dilution of 1: 600 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |