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| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | LAT2 rabbit polyclonal antibody |
Gene Name: | Large neutral amino acids transporter small subunit 2 |
Synonyms: | L-type amino acid transporter 2, mLAT2, Solute carrier family 7 member 8, Slc7a8, Lat2 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse LAT2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane, Cytoplasm |
Uniprot ID: | Q9WVR6 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 300-1: 2000 | jejunum, kidney, ovary, small intestine, stomach, testis |
Background
L-amino acid transporter protein-2 (LAT2), a non-glycosylated membrane protein, complexes with CD98 to contribute to readsorption of neutral amino acids in renal epithelia and blood-tissue barriers. The gene encoding LAT2 is expressed primarily in the kidney, but also to a lesser extent in placenta, brain, liver, spleen, skeletal muscle, heart, small intestine, and lung. Transfection with the antisense sequence of LAT2 suggests that LAT2 expression plays a major role in net basolateral efflux of cysteine, and points to LAT2 as a candidate gene to modulate cysteine reabsorption.
Images
 | Immunohistochemistry of paraffin embedded mouse jejunum using SLC7A8 (GB112950) at dilution of 1:1100 (400x lens) |
 | Immunohistochemistry of paraffin embedded mouse kidney using SLC7A8 (GB112950) at dilution of 1:1100 (400x lens) |
 | Immunohistochemistry of paraffin embedded mouse stomach using SLC7A8 (GB112950) at dilution of 1:1100 (400x lens) |
 | Immunohistochemistry of paraffin embedded mouse testis using SLC7A8 (GB112950) at dilution of 1:1100 (400x lens) |
 | Immunohistochemistry of paraffin embedded rat kidney using SLC7A8 (GB112950) at dilution of 1:1100 (400x lens) |
 | Immunohistochemistry of paraffin embedded rat stomach using SLC7A8 (GB112950) at dilution of 1:1100 (400x lens) |
 | Immunohistochemistry of paraffin embedded rat testis using SLC7A8 (GB112950) at dilution of 1:1100 (400x lens) |
 | Immunofluorescence of paraffin embedded mouse kidney using SLC7A8 (GB112950) at dilution of 1:300 (400x lens) |
 | Immunofluorescence of paraffin embedded mouse small intestine using SLC7A8 (GB112950) at dilution of 1:300 (400x lens) |
 | Immunofluorescence of paraffin embedded rat kidney using SLC7A8 (GB112950) at dilution of 1:300 (400x lens) |
| Immunofluorescence of paraffin embedded rat ovary using SLC7A8 (GB112950) at dilution of 1:300 (400x lens) |
| Immunofluorescence of paraffin embedded rat small intestine using SLC7A8 (GB112950) at dilution of 1:300 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |